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Carney complex and its subsets LAMB syndrome and NAME syndrome〔 are autosomal dominant conditions comprising myxomas of the heart and skin, hyperpigmentation of the skin (lentiginosis), and endocrine overactivity. It is distinct from Carney's triad. Approximately 7% of all cardiac myxomas are associated with Carney complex. ==Clinical features== The spotty skin pigmentation and lentigines occur most commonly on the face, especially on the lips, eyelids, conjunctiva, and oral mucosa.〔 Cardiac myxomas may lead to embolic strokes and heart failure〔 and may present with fever, joint pain, shortness of breath, diastolic rumble, and tumor plop. Myxomas may also occur outside the heart, usually in the skin and breast. Endocrine tumors may manifest as disorders such as Cushing syndrome. The most common endocrine gland manifestation is an ACTH-independent Cushing's syndrome due to primary pigmented nodular adrenocortical disease (PPNAD). The LAMB acronym refers to lentigines, atrial myxomas, and blue nevi.〔 NAME refers to nevi, atrial myxoma, myxoid neurofibromas, and ephelides.〔 Testicular cancer, particularly Sertoli cell type, is associated with Carney syndrome.〔Campbell Walsh urology, 10th edition, page 1693〕 Thyroid and pancreas cancer may also occur. Although J. Aiden Carney also described Carney's triad it is entirely different. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Carney complex」の詳細全文を読む スポンサード リンク
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